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Introducing Enhanced Profile Estrogen

FOR INVESTOR RELEASE

November 12th, 2024

Introduction

Transgender women suffer from many issues societal and chemical. Hormone Replacement Therapy, despite its age, is still a bit of a medical backwater. In particular, healthcare is difficult for many transgender women to find and maintain consistently. This is exacerbated by a high comorbidity of depression and executive dysfunction, therefore the medication schedules are often difficult for trans women to maintain.

Oral estrogen is the most common way for trans women to take exogenous hormones. This is convenient and simple, but highly sensitive to timing as the half-life of the estrogen in this form is extremely short and thus necessitates multiple doses over the course of the day. This is in part due to the low absorption efficiency and a high degree of first pass metabolic action from the liver. Patches are effective for some trans women but less so for others depending on skin vascularization. Intramuscular or subcutaneous injections are highly effective but the injection is difficult for many to self-administer. Pellets are long lasting but highly inconsistent.

Synthetic estrogens are a possible solution, but they have had substantial side effect profiles that have reduced their general application to cisgender women and thus eliminated their market, preventing so much as evaluation on transgender women. We have developed Enhanced Profile Estrogen to address these issues and provide enhanced targeting to trans women.

What is it?

Enhanced Profile Estrogen is a modified estrogen with a substituted group(structure under embargo until the patent is granted). This substituted group may be any of a number of classes of structures that provide different targeting, metabolic, and other effects.

The current structure of interest is referred to as Albany. This provides substantial improvements to the mood improving effects on dysphoric trans women, increases the metabolic half life by a factor of four, permitting pills to be a much smaller dosage and build up to a stable level like injections or patches. A beneficial secondary effect is that it enhances the tendency of the body to produce estrogen.

In addition it has interesting psychological effects, in that it diminishes the dysphoria directly, including in cisgender males. This is useful for some circumstances, but not ideal, and as such we are developing a companion structure Rochester that will hopefully dampen the feminizing effects while retaining the more infrequent dosing schedule.

Reagent Albany is a highly stable self catalyzing organic molecule that attaches to Estradiol and cleaves a space for itself. In our manufacturing process, estradiol is heated to 50 degrees Celsius in an aqueous solution which enhances the speed and completeness of the reaction with estradiol.

The product is siphoned off and the rest is placed back to circulate until it has reacted.

Reagent Albany is not known to display any acutely toxic effects on its own, however as it is not intended for human consumption we have not run a comprehensive review of it. A researcher did not notice any effects when she was believed to have absorbed a few hundred milligrams through her skin. She tested positive for the reagent for 12 months afterwards.

Patient Testimony

“Would you introduce yourself?”

“Uh, hi, I’m Melanie. EPE has been really good for me, I’ve been trans for the last two years and I’ve gotten a lot of great development. It worked a lot better for me with the ability to take fewer doses.”

“How have things in your personal life gone?”

“Mixed. My wife didn’t like that I was transitioning. I think at least part of it was seeing parts of me that she loved of me, some of which were associated with being a man, drift away. I did find out who my real friends were. Whatever that means”

“How do you feel about the physical effects the drug has had on you?”

“I like it. I mean, It’s not quite perfect. I mean, I guess I have the biggest breasts in the family so I don’t think I’ve gotten a bad deal from it. The reduction in dysphoria was really nice, especially earlier on in my transition. I can just use normal estradiol now without any issues.”

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